The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, sponsors Neuroprotection Exploratory Trials in Parkinson’s Disease (NET-PD). NET-PD was a series of clinical research studies conducted at more than 50 centers across the country in an effort to find drugs to slow the progression of Parkinson’s.
Recruitment for the pilot NET-PD studies is now complete, and testing of the potential neuroprotective agents is underway. Compounds that appear promising in this pilot phase may have been evaluated in larger, more definitive Phase III trials. Furthermore, if additional neuroprotective agents show sufficient promise, it is also possible that additional pilot studies may be developed.
Participating in a clinical study allows you to play an active role in developing future treatments for diseases. For current studies please visit clinicaltrials.gov.
For more information about Parkinson’s disease research, visit the NINDS PD research page.
According to research findings released May 4th, 2020 and reported on AJMC, men with modest alcohol consumption are at a greater risk of getting Parkinson’s when compared to very light drinkers. However, the research concluded that there is no significant link between alcohol consumption and the risk of Parkinson’s Disease. The study references research publications from PubMed.gov and is supported by national alcohol and drug recovery resource, victoryoflife.com.
Parkinson’s Disease is a condition involving the nervous system that affects movement, which often includes tremors. Nerve cell damage in the brain causes dopamine levels to drop, leading to the abnormal movements caused by the disease. Learn more here.
There are a range of symptoms and signs of Parkinson’s Disease and they can differ from person to person. Typically, symptoms start on one side of the body and tend to remain worse on that side.
Known symptoms and signs include:
Unfortunately, there is currently no treatment that can cure Parkinson’s Disease. However, there are certain treatments readily available to aid in easing the signs and symptoms.
Treatment for Parkinson’s Disease varies by patient and is based on a persons signs and symptoms. Treatments can consist of surgical therapy, medications and certain lifestyle changes.
There are many drugs offered to treat signs and symptoms. However, none of them are known to completely reverse the impacts of the condition. It is typically recommended for individuals with Parkinson’s Disease to take a variety of these medicines.
It is unknown what causes Parkinson’s disease. However, there are certain factors that play a role:
Genetics. Research has identified that Parkinson’s Disease can be caused be certain genetic mutations. These tend to be unlikely except in specific cases with more than one family member that has history of the disease.
With that said, there are certain gene variations that have been found to increase the chances of Parkinson’s Disease (uncommon).
There is no specific test designed to diagnose Parkinson’s Disease. Neurologists diagnose the disease based on a patients signs and symptoms, medical history and physical examination.
Parkinson’s Disease may cause change in speech and speech difficulty. Here are some of the changes that may be observed:
Yes. These are potential symptoms of Parkinson’s disease often referred to as PD psychosis. Typically, hallucinations are a result of side effects from medications prescribed for the disease. These hallucinations can be:
Parkinson’s Disease is best known for causing neurogenic orthostatic hypotension (nOH). However, it can also cause heart rhythm abnormalities. It continues to be unknown how significant are the consequences of these abnormalities.
Heart conditions such as coronary artery disease or cardiomyopathy are not thought to belong to the pathology of Parkinson’s Disease, but can co-exist. If you or someone you know is suffering from chest pain, please contact your cardiologist for a cardiac evaluation.
Disclaimer: Some of the content on this page is archived and provided for reference purposes only. NINDS is no longer affiliated with this website and does not update this information, but it may be useful as a reference or resource.